Investigating the role of DNA damage in tobacco smoking-induced spine degeneration.
Identifieur interne : 000126 ( Canada/Analysis ); précédent : 000125; suivant : 000127Investigating the role of DNA damage in tobacco smoking-induced spine degeneration.
Auteurs : Luigi A. Nasto [Italie] ; Kevin Ngo [États-Unis] ; Adriana S. Leme [États-Unis] ; Andria R. Robinson [États-Unis] ; Qing Dong [États-Unis] ; Peter Roughley [Canada] ; Arvydas Usas [États-Unis] ; Gwendolyn A. Sowa [États-Unis] ; Enrico Pola [Italie] ; James Kang [États-Unis] ; Laura J. Niedernhofer [États-Unis] ; Steven Shapiro [États-Unis] ; Nam V. Vo [États-Unis]Source :
- The spine journal : official journal of the North American Spine Society [ 1878-1632 ] ; 2014.
Descripteurs français
- KwdFr :
- Agrécanes (métabolisme), Altération de l'ADN (physiologie), Animaux, Disque intervertébral (imagerie diagnostique), Disque intervertébral (métabolisme), Dégénérescence de disque intervertébral (imagerie diagnostique), Dégénérescence de disque intervertébral (physiopathologie), Dégénérescence de disque intervertébral (étiologie), Facteurs de risque, Femelle, Microtomographie aux rayons X, Modèles animaux de maladie humaine, Mâle, Protéoglycanes (métabolisme), Souris, Souris de lignée C57BL, Tabagisme (effets indésirables).
- MESH :
- effets indésirables : Tabagisme.
- imagerie diagnostique : Disque intervertébral, Dégénérescence de disque intervertébral.
- métabolisme : Agrécanes, Disque intervertébral, Protéoglycanes.
- physiologie : Altération de l'ADN.
- physiopathologie : Dégénérescence de disque intervertébral.
- étiologie : Dégénérescence de disque intervertébral.
- Animaux, Facteurs de risque, Femelle, Microtomographie aux rayons X, Modèles animaux de maladie humaine, Mâle, Souris, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Aggrecans (metabolism), Animals, DNA Damage (physiology), Disease Models, Animal, Female, Intervertebral Disc (diagnostic imaging), Intervertebral Disc (metabolism), Intervertebral Disc Degeneration (diagnostic imaging), Intervertebral Disc Degeneration (etiology), Intervertebral Disc Degeneration (physiopathology), Male, Mice, Mice, Inbred C57BL, Proteoglycans (metabolism), Risk Factors, Smoking (adverse effects), X-Ray Microtomography.
- MESH :
- chemical , metabolism : Aggrecans, Proteoglycans.
- adverse effects : Smoking.
- diagnostic imaging : Intervertebral Disc, Intervertebral Disc Degeneration.
- etiology : Intervertebral Disc Degeneration.
- metabolism : Intervertebral Disc.
- physiology : DNA Damage.
- physiopathology : Intervertebral Disc Degeneration.
- Animals, Disease Models, Animal, Female, Male, Mice, Mice, Inbred C57BL, Risk Factors, X-Ray Microtomography.
Abstract
Tobacco smoking is a key risk factor for spine degeneration. However, the underlying mechanism by which smoking induces degeneration is not known. Recent studies implicate DNA damage as a cause of spine and intervertebral disc degeneration. Because tobacco smoke contains many genotoxins, we hypothesized that tobacco smoking promotes spine degeneration by inducing cellular DNA damage.
DOI: 10.1016/j.spinee.2013.08.034
PubMed: 24211096
Affiliations:
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pubmed:24211096Le document en format XML
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Sowa</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopaedic Surgery, Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopaedic Surgery, Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Pola, Enrico" sort="Pola, Enrico" uniqKey="Pola E" first="Enrico" last="Pola">Enrico Pola</name><affiliation wicri:level="1"><nlm:affiliation>Department of Orthopaedic Surgery, Catholic University of Rome School of Medicine, "A. 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Nasto</name><affiliation wicri:level="1"><nlm:affiliation>Department of Orthopaedic Surgery, Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Orthopaedic Surgery, Catholic University of Rome School of Medicine, "A. Gemelli" University Hospital, l.go Agostino Gemelli 8, 00168 Roma, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Orthopaedic Surgery, Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Orthopaedic Surgery, Catholic University of Rome School of Medicine, "A. Gemelli" University Hospital, l.go Agostino Gemelli 8, 00168 Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Ngo, Kevin" sort="Ngo, Kevin" uniqKey="Ngo K" first="Kevin" last="Ngo">Kevin Ngo</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopaedic Surgery, Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopaedic Surgery, Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Leme, Adriana S" sort="Leme, Adriana S" uniqKey="Leme A" first="Adriana S" last="Leme">Adriana S. Leme</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Pittsburgh School of Medicine, 3550 Terrace St, Pittsburgh, PA 15213, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Pittsburgh School of Medicine, 3550 Terrace St, Pittsburgh, PA 15213</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Robinson, Andria R" sort="Robinson, Andria R" uniqKey="Robinson A" first="Andria R" last="Robinson">Andria R. Robinson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Dong, Qing" sort="Dong, Qing" uniqKey="Dong Q" first="Qing" last="Dong">Qing Dong</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopaedic Surgery, Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopaedic Surgery, Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Roughley, Peter" sort="Roughley, Peter" uniqKey="Roughley P" first="Peter" last="Roughley">Peter Roughley</name><affiliation wicri:level="1"><nlm:affiliation>McGill Scoliosis and Spine Group, Genetics Unit, Shriners Hospital for Children, Montreal, Quebec H3G 1A6, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>McGill Scoliosis and Spine Group, Genetics Unit, Shriners Hospital for Children, Montreal, Quebec H3G 1A6</wicri:regionArea><wicri:noRegion>Quebec H3G 1A6</wicri:noRegion></affiliation></author><author><name sortKey="Usas, Arvydas" sort="Usas, Arvydas" uniqKey="Usas A" first="Arvydas" last="Usas">Arvydas Usas</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopaedic Surgery of UPMC, Stem Cell Research Center, Pittsburgh, PA 15261, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopaedic Surgery of UPMC, Stem Cell Research Center, Pittsburgh, PA 15261</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Sowa, Gwendolyn A" sort="Sowa, Gwendolyn A" uniqKey="Sowa G" first="Gwendolyn A" last="Sowa">Gwendolyn A. Sowa</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopaedic Surgery, Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopaedic Surgery, Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Pola, Enrico" sort="Pola, Enrico" uniqKey="Pola E" first="Enrico" last="Pola">Enrico Pola</name><affiliation wicri:level="1"><nlm:affiliation>Department of Orthopaedic Surgery, Catholic University of Rome School of Medicine, "A. Gemelli" University Hospital, l.go Agostino Gemelli 8, 00168 Roma, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Orthopaedic Surgery, Catholic University of Rome School of Medicine, "A. Gemelli" University Hospital, l.go Agostino Gemelli 8, 00168 Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Kang, James" sort="Kang, James" uniqKey="Kang J" first="James" last="Kang">James Kang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopaedic Surgery, Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopaedic Surgery, Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Niedernhofer, Laura J" sort="Niedernhofer, Laura J" uniqKey="Niedernhofer L" first="Laura J" last="Niedernhofer">Laura J. Niedernhofer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; Department of Metabolism and Aging, The Scripps Research Institute, 130 Scripps Way #3B3, Jupiter, FL 33458-5284, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; Department of Metabolism and Aging, The Scripps Research Institute, 130 Scripps Way #3B3, Jupiter, FL 33458-5284</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Shapiro, Steven" sort="Shapiro, Steven" uniqKey="Shapiro S" first="Steven" last="Shapiro">Steven Shapiro</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Pittsburgh School of Medicine, 3550 Terrace St, Pittsburgh, PA 15213, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Pittsburgh School of Medicine, 3550 Terrace St, Pittsburgh, PA 15213</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Vo, Nam V" sort="Vo, Nam V" uniqKey="Vo N" first="Nam V" last="Vo">Nam V. Vo</name><affiliation wicri:level="2"><nlm:affiliation>Department of Orthopaedic Surgery, Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address: von@upmc.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Orthopaedic Surgery, Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j">The spine journal : official journal of the North American Spine Society</title><idno type="eISSN">1878-1632</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aggrecans (metabolism)</term><term>Animals</term><term>DNA Damage (physiology)</term><term>Disease Models, Animal</term><term>Female</term><term>Intervertebral Disc (diagnostic imaging)</term><term>Intervertebral Disc (metabolism)</term><term>Intervertebral Disc Degeneration (diagnostic imaging)</term><term>Intervertebral Disc Degeneration (etiology)</term><term>Intervertebral Disc Degeneration (physiopathology)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Proteoglycans (metabolism)</term><term>Risk Factors</term><term>Smoking (adverse effects)</term><term>X-Ray Microtomography</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Agrécanes (métabolisme)</term><term>Altération de l'ADN (physiologie)</term><term>Animaux</term><term>Disque intervertébral (imagerie diagnostique)</term><term>Disque intervertébral (métabolisme)</term><term>Dégénérescence de disque intervertébral (imagerie diagnostique)</term><term>Dégénérescence de disque intervertébral (physiopathologie)</term><term>Dégénérescence de disque intervertébral (étiologie)</term><term>Facteurs de risque</term><term>Femelle</term><term>Microtomographie aux rayons X</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Protéoglycanes (métabolisme)</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Tabagisme (effets indésirables)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Aggrecans</term><term>Proteoglycans</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Intervertebral Disc</term><term>Intervertebral Disc Degeneration</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Tabagisme</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Intervertebral Disc Degeneration</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Disque intervertébral</term><term>Dégénérescence de disque intervertébral</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Intervertebral Disc</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Agrécanes</term><term>Disque intervertébral</term><term>Protéoglycanes</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Altération de l'ADN</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>DNA Damage</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Dégénérescence de disque intervertébral</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Intervertebral Disc Degeneration</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Dégénérescence de disque intervertébral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Risk Factors</term><term>X-Ray Microtomography</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Facteurs de risque</term><term>Femelle</term><term>Microtomographie aux rayons X</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Souris</term><term>Souris de lignée C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Tobacco smoking is a key risk factor for spine degeneration. However, the underlying mechanism by which smoking induces degeneration is not known. Recent studies implicate DNA damage as a cause of spine and intervertebral disc degeneration. Because tobacco smoke contains many genotoxins, we hypothesized that tobacco smoking promotes spine degeneration by inducing cellular DNA damage.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Italie</li><li>États-Unis</li></country><region><li>Floride</li><li>Latium</li><li>Pennsylvanie</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><region name="Latium"><name sortKey="Nasto, Luigi A" sort="Nasto, Luigi A" uniqKey="Nasto L" first="Luigi A" last="Nasto">Luigi A. Nasto</name></region><name sortKey="Pola, Enrico" sort="Pola, Enrico" uniqKey="Pola E" first="Enrico" last="Pola">Enrico Pola</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Ngo, Kevin" sort="Ngo, Kevin" uniqKey="Ngo K" first="Kevin" last="Ngo">Kevin Ngo</name></region><name sortKey="Dong, Qing" sort="Dong, Qing" uniqKey="Dong Q" first="Qing" last="Dong">Qing Dong</name><name sortKey="Kang, James" sort="Kang, James" uniqKey="Kang J" first="James" last="Kang">James Kang</name><name sortKey="Leme, Adriana S" sort="Leme, Adriana S" uniqKey="Leme A" first="Adriana S" last="Leme">Adriana S. Leme</name><name sortKey="Niedernhofer, Laura J" sort="Niedernhofer, Laura J" uniqKey="Niedernhofer L" first="Laura J" last="Niedernhofer">Laura J. Niedernhofer</name><name sortKey="Robinson, Andria R" sort="Robinson, Andria R" uniqKey="Robinson A" first="Andria R" last="Robinson">Andria R. Robinson</name><name sortKey="Shapiro, Steven" sort="Shapiro, Steven" uniqKey="Shapiro S" first="Steven" last="Shapiro">Steven Shapiro</name><name sortKey="Sowa, Gwendolyn A" sort="Sowa, Gwendolyn A" uniqKey="Sowa G" first="Gwendolyn A" last="Sowa">Gwendolyn A. Sowa</name><name sortKey="Usas, Arvydas" sort="Usas, Arvydas" uniqKey="Usas A" first="Arvydas" last="Usas">Arvydas Usas</name><name sortKey="Vo, Nam V" sort="Vo, Nam V" uniqKey="Vo N" first="Nam V" last="Vo">Nam V. Vo</name></country><country name="Canada"><noRegion><name sortKey="Roughley, Peter" sort="Roughley, Peter" uniqKey="Roughley P" first="Peter" last="Roughley">Peter Roughley</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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